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Latest News
Integrative Biology board member Roger Tsien wins Nobel Prize
08 October 2008
The Nobel Prize in Chemistry has been awarded to Roger Tsien, a member of the editorial board for RSC's Integrative Biology
Chips & Tips: Reusable, robust NanoPort connections to PDMS chips
08 October 2008
Jesse Greener and colleagues describe how to make reusable, robust NanoPort connections to PDMS chips
The barcode and the bioassay
08 October 2008
Mini-barcodes are used to track DNA samples like luggage at an airport
Chip measures channel currents
07 October 2008
Non-invasive chip technology offers order-of-magnitude improvement for ion channel studies
Contents list for Lab on a Chip, issue 10, 2008
Front cover
Lab Chip, 2008, 8, 1589
DOI: 10.1039/b815780b
Inside front cover
Lab Chip, 2008, 8, 1590
DOI: 10.1039/b815782k
Contents and Chemical Technology
Lab Chip, 2008, 8, 1591
DOI: 10.1039/b815783a
Highlight
Research Highlights
Lab Chip, 2008, 8, 1601
DOI: 10.1039/b814906m
Petra Dittrich reviews the current literature in miniaturisation and related technologies.
Critical Review
MEMS and the microbe
Colin J. Ingham and Johan E. T. van Hylckama Vlieg,
Lab Chip, 2008, 8, 1604
DOI: 10.1039/b804790a
Microengineers and microbiologists deal with a common scale and are now cooperating and innovating within the MEMS field.
Communications
Formation of artificial lipid bilayers using droplet dielectrophoresis
Sara Aghdaei, Mairi E. Sandison, Michele Zagnoni, Nicolas G. Green and Hywel Morgan,
Lab Chip, 2008, 8, 1617
DOI: 10.1039/b807374k
Formation of artificial bilayer lipid membranes is achieved by the controlled, electrical manipulation of aqueous droplets immersed in a lipid–alkane solution using dielectrophoresis on planar microelectrodes covered in a thin insulator. The method produced BLMs suitable for single-channel recording of membrane protein activity.
Self-loading lithographically structured microcontainers: 3D patterned, mobile microwells
Timothy G. Leong, Christina L. Randall, Bryan R. Benson, Aasiyeh M. Zarafshar and David H. Gracias,
Lab Chip, 2008, 8, 1621
DOI: 10.1039/b809098j
We demonstrate mass-producible, mobile, patterned 3D microcontainers that self-load cells, embryos and beads.
Papers
Electrokinetically driven fluidic transport in integrated three-dimensional microfluidic devices incorporating gold-coated nanocapillary array membranes
Aigars Piruska, Sean Branagan, Donald M. Cropek, Jonathan V. Sweedler and Paul W. Bohn,
Lab Chip, 2008, 8, 1625
DOI: 10.1039/b805768k
Gold island-coated NCAMs support analyte injections, but continuous gold films lead to suppressed injections and to ion enrichment/depletion effects.
Biocompatible surfactants for water-in-fluorocarbon emulsions
C. Holtze, A. C. Rowat, J. J. Agresti, J. B. Hutchison, F. E. Angilè, C. H. J. Schmitz, S. Köster, H. Duan, K. J. Humphry, R. A. Scanga, J. S. Johnson, D. Pisignano and D. A. Weitz,
Lab Chip, 2008, 8, 1632
DOI: 10.1039/b806706f
A novel non-ionic fluorosurfactant stabilizes drops of a water-in-oil emulsion and facilitates in vitro transcription and translation of genes into proteins as shown by the accumulation of fluorescent product inside the drops. Drop size: 20 
m.
Microfluidic-based synthesis of non-spherical magnetic hydrogel microparticles
Dae Kun Hwang, Dhananjay Dendukuri and Patrick S. Doyle,
Lab Chip, 2008, 8, 1640
DOI: 10.1039/b805176c
A T-junction microfluidic device in combination with a UV light reflector has been developed to controllably synthesize magnetic hydrogel particles in spherical and non-spherical forms.
An integrated QCM-based narcotics sensing microsystem
Thomas Frisk, Niklas Sandström, Lars Eng, Wouter van der Wijngaart, Per Månsson and Göran Stemme,
Lab Chip, 2008, 8, 1648
DOI: 10.1039/b800487k
An integrated narcotics sensing microsystem with a perforated silicon diaphragm interface for trapping of airborne molecules and analysis in an immunohistological assay on a quartz crystal microbalance.
A microfluidic flow injection system for DNA assay with fluids driven by an on-chip integrated pump based on capillary and evaporation effects
Zhang-Run Xu, Chong-Hui Zhong, Yan-Xia Guan, Xu-Wei Chen, Jian-Hua Wang and Zhao-Lun Fang,
Lab Chip, 2008, 8, 1658
DOI: 10.1039/b805774e
A micro-pump based on capillary and evaporation effects using a filter paper plug was integrated on a chip, and a miniaturized flow injection analysis system was developed for DNA assay.
A soft-polymer piezoelectric bimorph cantilever-actuated peristaltic micropump
Neil J. Graf and Michael T. Bowser,
Lab Chip, 2008, 8, 1664
DOI: 10.1039/b805252b
A microscale peristaltic pump with piezoelectric actuation is fabricated in a PDMS substrate using a simple wire mold technology. This device is capable of producing low flow rates (0–250 nL min-1) while generating high back pressures (35 kPa).
Electric field control and analyte transport in Si/SiO2 fluidic nanochannels
Yi Zhang, Thomas C. Gamble, Alexander Neumann, Gabriel P. Lopez, Steven R. J. Brueck and Dimiter N. Petsev,
Lab Chip, 2008, 8, 1671
DOI: 10.1039/b804256j
This article presents an analysis of the electric field distribution and current transport in fluidic nanochannels fabricated by etching of a silicon chip.
Laser-induced cavitation based micropump
Rory Dijkink and Claus-Dieter Ohl,
Lab Chip, 2008, 8, 1676
DOI: 10.1039/b806912c
A microfluidic pump based on a cavitation bubble which develops a high-speed liquid yet. The bubble is created with a pulsed laser, thus it keeps PDMS based designs simple.
Influence of micromixer characteristics on polydispersity index of block copolymers synthesized in continuous flow microreactors
Carine Rosenfeld, Christophe Serra, Cyril Brochon and Georges Hadziioannou,
Lab Chip, 2008, 8, 1682
DOI: 10.1039/b803885f
Continuous block copolymerizations using different micromixers have highlighted a linear relationship between the polydispersity index of the copolymer and a form factor related to the characteristic dimensions of the micromixer.
Perforated membrane method for fabricating three-dimensional polydimethylsiloxane microfluidic devices
Yiqi Luo and Richard N. Zare,
Lab Chip, 2008, 8, 1688
DOI: 10.1039/b807751g
Through-holes (vias) that connect different layers are fabricated in a PDMS microfluidic device using a perforated membrane method, which allows simple and rapid prototyping.
Versatile control of multiphase laminar flow for in-channel microfabrication
Yunxiang Gao and Liwei Chen,
Lab Chip, 2008, 8, 1695
DOI: 10.1039/b807468b
We have improved the multiphase laminar flow based in-channel fabrication method to overcome diffusion-induced broadening.
Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel
Shannon Faley, Kevin Seale, Jacob Hughey, David K. Schaffer, Scott VanCompernolle, Brett McKinney, Franz Baudenbacher, Derya Unutmaz and John P. Wikswo,
Lab Chip, 2008, 8, 1700
DOI: 10.1039/b719799c
The multitrap nanophysiometer for the trapping, long-term maintenance and observation of unattached primary human immune cells. The figure shows its design, its implementation in PDMS, and sequential images demonstrating the trapping of human T cells.
A microarray to measure repair of damaged plasmids by cell lysates
J.-F. Millau, A.-L. Raffin, S. Caillat, C. Claudet, G. Arras, N. Ugolin, T. Douki, J.-L. Ravanat, J. Breton, T. Oddos, C. Dumontet, A. Sarasin, S. Chevillard, A. Favier and S. Sauvaigo,
Lab Chip, 2008, 8, 1713
DOI: 10.1039/b806634e
The in vitro miniaturized assay described here allowed quantifying excision/synthesis activities in cell lysates. Repair of a panel of DNA lesions (photo-induced, oxidative, drug-induced) could be measured simultaneously yielding highly specific DNA repair phenotypes.
Microfluidic patterning of nanodisc lipid bilayers and multiplexed analysis of protein interaction
Edgar D. Goluch, Andrew W. Shaw, Stephen G. Sligar and Chang Liu,
Lab Chip, 2008, 8, 1723
DOI: 10.1039/b806733c
We demonstrate the ability to create precise patterns of lipid bilayers, with stoichiometric control over composition, by using microfluidics in combination with nanoscale lipid bilayer constructs known as Nanodiscs. The utility of such patterns is shown by analyzing protein interactions with the lipid bilayers in a multiplexed fashion.
Technical Notes
Ionic current rectification at a nanofluidic/microfluidic interface with an asymmetric microfluidic system
Scott A. Miller, Kathleen C. Kelly and Aaron T. Timperman,
Lab Chip, 2008, 8, 1729
DOI: 10.1039/b808179d
Rectification of current is produced by an asymmetric microfluidic device that has symmetric nanocapillaries with a microfluidic channel on one side and a macroscopic reservoir on the opposite side.
An active bubble trap and debubbler for microfluidic systems
Alison M. Skelley and Joel Voldman,
Lab Chip, 2008, 8, 1733
DOI: 10.1039/b807037g
A novel, 2-layer PDMS debubbler is presented that can trap and remove bubbles (up to 25 L in 3 h) during continuous normal device operation.
Side-by-side comparison of disposable microchips with commercial capillary cartridges for application in capillary isoelectric focusing with whole column imaging detection
Zhen Liu, Junjie Ou, Razim Samy, Tomasz Glawdel, Tiemin Huang, Carolyn L. Ren and Janusz Pawliszyn,
Lab Chip, 2008, 8, 1738
DOI: 10.1039/b807646d
Disposable PDMS microchips were developed for capillary isoelectric focusing with whole column imaging detection. Comparison with commercial capillary cartridges demonstrated that the disposable microchips have comparable performance and several advantages.
Long-term storable and shippable lipid bilayer membrane platform
Tae-Joon Jeon, Jason L. Poulos and Jacob J. Schmidt,
Lab Chip, 2008, 8, 1742
DOI: 10.1039/b807932c
We have successfully created and demonstrated a lipid bilayer membrane platform capable of long term storage and commercial shipping based on the solidification of a membrane precursor through freezing.
Neutravidin micropatterning by deep UV irradiation
Ying-Ming Huang, Maruti Uppalapati, William Olaf Hancock and Thomas Nelson Jackson,
Lab Chip, 2008, 8, 1745
DOI: 10.1039/b802762e
We describe a technique for patterning surface-adsorbed neutravidin by drying the protein using acetone and then ablating the protein in selected areas using deep UV illumination.
Back matter
Lab Chip, 2008, 8, 1748
DOI: 10.1039/b815786n
Back cover
Lab Chip, 2008, 8, 1751
DOI: 10.1039/b815787c
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