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Lab on a Chip

Microfluidic and nanotechnologies for chemistry, biology, and bioengineering



Further News

moth implants

Spy moths controlled by chemicals

26 November 2008

US researchers control moth flight using microfluidic implants


Lab on a Chip Issue 12, 2008

Lab on a Chip Themed Issue: Point-of-Care Diagnostics

19 November 2008

This special issue captures some of the leading directions and themes of today's research.


Chemical Technology

Issue 12 of Chemical Technology now published

19 November 2008

Drawing together the best content from all RSC publications to highlight the latest applications and technological aspects of research.


Rendered cells

First articles now online

18 November 2008

Read the first Advance Articles for Metallomics online for free


cells

First articles now online

13 November 2008

Read the first Advance Articles for Integrative Biology


scanned images of capillary tubes with biomolecules attached internally

Cheaper than chips

03 November 2008

Capillary tubes may offer an inexpensive alternative to on-chip diagnostics, say French scientists.


A drop of blood on a fingertip

Immune function on a chip

30 October 2008

Rapid white blood cell monitoring requires only a drop of blood


Microscale version of Girl with a Pearl Earring

Lasers draw protein pictures

30 October 2008

Scientists have recreated a famous painting on the microscale using a new protein patterning technique


Malaria-carrying mosquito

Sweet solution for on-card reagent storage

29 October 2008

Storing dry reagents on microfluidic cards could lead to easier disease diagnosis in the developing world


Lab on a Chip submissions

24 issues and George Whitesides as new Editorial Board Chair for 2009

24 October 2008

Lab on a Chip community helps ascend the journal to the next level


Andreas Manz

An Extraordinary Chair Retires

24 October 2008

Andreas Manz retires as Lab on a Chip Editorial Board Chair


Art Award Image

Lab on a Chip awards Prizes at µTAS 2008

24 October 2008

Find out who won this year's Prizes at µTAS


Microchannel device for protein expression screening

Passive pumping promotes protein production

24 October 2008

Time-saving device screens nearly 200 protein syntheses in parallel and reduces amounts of reagents required


cutting PDMS

Chips & Tips: Profile measurement for microstructures made in hard material

22 October 2008

Jie Xu and Daniel Attinger explain a method for profile measurement for microstructures made in hard material


Botulinum toxin A

Microfluidics joins fight against bioweapon

17 October 2008

A new bead-based sensor can detect trace levels of a lethal neurotoxin


Information Symbol

Your RSC subscriptions and free content

16 October 2008

Find out what you can access, and where to find free content


Modified egg beater

Lab-on-an-egg-beater

15 October 2008

Scientists whip up new centrifuge using kitchen utensil


PDMS rings

Chips & Tips: Reusable, robust NanoPort connections to PDMS chips

08 October 2008

Jesse Greener and colleagues describe how to make reusable, robust NanoPort connections to PDMS chips


Jellyfish

Integrative Biology board member Roger Tsien wins Nobel Prize

08 October 2008

The Nobel Prize in Chemistry has been awarded to Roger Tsien, a member of the editorial board for RSC's Integrative Biology


Kerr microscope reading a barcode-labelled DNA sample

The barcode and the bioassay

08 October 2008

Mini-barcodes are used to track DNA samples like luggage at an airport


Disposable chip for non-invasive electrophysiological measurements

Chip measures channel currents

07 October 2008

Non-invasive chip technology offers order-of-magnitude improvement for ion channel studies


The path of an Escherichia coli cell through a ratchet

Sorting swimming cells

02 October 2008

US scientists are using chip technology to make bacteria sort themselves by size


A 4 × 4 array of cells trapped in a hydrogel

Tiling yields model tissue

01 October 2008

US scientists are mimicking tissue by fixing together tiles of cells


electrodes crossing a microchannel

Chips & Tips: Rapid prototyping of a PMMA microfluidic chip with integrated platinum electrodes

18 September 2008

Martin Arundell and co-workers report a method for rapid prototyping of PMMA microfluidic chips with integrated platinum electrodes


Cubic container loaded with glass beads

Microcontainers hold cells captive

19 September 2008

Self-loading porous containers provide a realistic environment for studying cells


Fluorescence image of emulsion droplets

The perfect surfactant

12 September 2008

Water droplets can be used as microvessels for biological assays thanks to a new surfactant developed by scientists in Europe and the US


paper microfluidic device shaped like Africa

Microfluidics in a FLASH

10 September 2008

US scientists have made microfluidic devices using only paper, a pen and sunlight


Microfluidic device

On-chip sequential cell treatment

29 July 2008

Cells can be subjected to different chemical treatments in a continuous sequence using a chip designed by US scientists


PDMS drop

Chips & Tips: Bonding & Sealing of components in PDMS by deposition of micro-drops of PDMS using micropipette

09 September 2008

Arash Noori and P. Ravi Selvaganapathy describe a method for bonding and sealing of components in PDMS


Droplet interface bilayer formed by two droplets suspended in oil

Hot article: droplet interface bilayers

05 September 2008

Hagan Bayley and colleagues at Oxford University review the development of droplet interface bilayers for the study of membrane proteins.


laminated chip

Chips & Tips: Lamination of Plastic Microfluidic Devices

30 July 2008

Daniel Olivero and Z. Hugh Fan present a simple method for lamination of plastic microfluidic devices


microfluidic channel

Chips & Tips: Quick Measurement of Electroosmotic Flow Velocity

10 July 2008

Motohiko Nohmi and Juan Santiago present a simple way of estimating electroosmotic flow velocities in channel geometries with at least one intersection.


A droplet-based microfluidic system

Droplet traps for worms on chip

29 July 2008

Watching how worms behave in droplets is the basis for a new assay that could find use in high-throughput drug screening


zigzag microreactor

Prices of microreactors stamped down

29 July 2008

Polymer-based microreactors turn inorganic to beat organic solvent attacks and reduce prices


A microfluidic reaction chamber with miniaturised luer fitting

Flow chemistry for the masses

08 July 2008

Two new build-your-own microfluidic systems promise to simplify the technology so the whole research community can use it


Test for methicillin-resistant Staphylococcus aureus

Faster superbug detection

07 July 2008

Chip technology could cut the wait for test results on clinical samples, US scientists say


Green fluorescent cells growing in microtubes

Tubular cells

01 July 2008

A new method for growing cylinders of living cells could be used for tissue engineering


Frances Ligler

Interview: Navy's sensing mission

01 July 2008

Frances Ligler tells Kathleen Too about portable, automated biosensors for fast, on-site detection of pathogens, toxins, pollutants, drugs and explosives


tiny hook holding DNA strand

Miniaturised sewing machines

23 June 2008

Single threads of DNA can now be manipulated using miniaturised hooks and bobbins, thanks to Japanese scientists


Protein separation on a gradient gel as a function of protein size and migration time

Sizing up proteins on-chip

13 June 2008

US scientists have formed gels on-chip for easier and cheaper protein separation


cells

New journal announced: Integrative Biology

12 June 2008

January 2009 will see Integrative Biology: Quantitative biosciences from nano to macro, launched by RSC Publishing


Book of Choice

Lab on a Chip Book of Choice

Take a look at the latest Lab on a Chip book of choice from RSC Books


Cells captured on a silicon cantilever in a microfluidic channel

Weighing up cells

11 June 2008

How much does a cell weigh? US chemists are using a miniature cantilever to find out


Staphylococcus aureus-antibody complex formation on the surface of the transistor

Electronic sensor for bad bacteria

02 June 2008

Toxins responsible for food poisoning can be detected using nanoscale transistors, claim US scientists.


ExoMars rover

Lab-on-a-chip looks for life on Mars

29 May 2008

NASA scientists have developed a new microfluidic system that is tough enough to be used in outer space.


holes in a PDMS block

Chips & Tips: See where to punch holes easily in a PDMS microfluidic device

29 May 2008

Amy Rowat and David Weitz describe how to see where to punch holes in a PDMS microfluidic device.


A fluorescent micrograph of the hydrogel-filled microdevice

Hydrogel helps the medicine go down

20 May 2008

US scientists have made an easy-to-swallow device to controllably deliver cancer drugs into the body.


A schematic illustration of an electrode showing holes in a cell monolayer above

Holey approach to wound healing research

19 May 2008

On-chip method allows fully automated cell migration studies.


filled reservoirs

Chips & Tips: Integrated Reservoirs for PDMS Microfluidic Chips

22 April 2008

T. Liu and co-workers present integrated reservoirs for PDMS microfluidic chips.


syringe

Chips & Tips: An easy temperature control system for syringe pumps

22 April 2008

Lorenzo Capretto and co-workers describe an easy temperature control system for syringe pumps.


on-chip filter

Chips & Tips: Microfabrication Design Guidelines for Glass Micro- and Nano-fluidic Devices

18 April 2008

Dave Huber and Sumita Pennathur give some useful microfabrication design guidelines for glass micro- and nano-fluidic devices.


The microfluidic device that can monitor immunoreactions

10 minute diagnosis on the microscale

15 April 2008

Scientists in the US have taken a step towards faster and more efficient immunoassays for diagnosing HIV and other diseases.


Aggregated platelets

Blood clotting on-chip

07 April 2008

Microfluidic technology could help unravel the complex role of clot formation in bleeding disorders.


Droplet moving on a vertical surface

Driving water droplets uphill

02 April 2008

Lab-on-a-chip technology could soon simplify a host of applications, thanks to a new way to move droplets up vertical surfaces on flexible chips.


A nose

The science of smell

18 March 2008

Chip technology is helping French scientists to unravel the mysteries behind our sense of smell.


Abstract image

Free access in April

14 March 2008

Online access to RSC journals provided for customers for the whole of April


Stretching device

To sort, simply stretch

11 March 2008

Researchers in Sweden have come up with a straightforward method for sorting particles in microfluidics - simply stretching the microchannel


Artificial cilia

Miniature mixing inspired by nature

06 March 2008

Dutch scientists have copied nature to develop a faster and more efficient method for mixing small volumes of liquid.


iPod

Visit us at the ACS Spring National Meeting for your chance to win an iPod

04 March 2008

Come and visit booth 411 at the ACS Spring National Meeting & Exposition in New Orleans, 6th to 10th April 2008


Glass-coated microchannel

Glass-coated microchannels

28 February 2008

Scientists in the US have developed a simple method of coating the channels of microfluidic devices to make them more resistant to chemicals.


bonded Upchurch Nanoport

Chips & Tips: Bonding Upchurch® NanoPorts to PDMS

12 February 2008

Corey Koch and co-workers describe a simple method to bond Upchurch® NanoPortsT to PDMS chips.


Molecular motor F1-ATPase

DNA detection with a twist

08 February 2008

US scientists have set DNA detection in a spin by exploiting one of nature's molecular motors.


Cell lysis in a microfluidic channel

Laser beam hits tiny target

30 January 2008

Chemists looking to analyse single cells have combined lab-on-a-chip techniques with lasers to burst the cells open.


The microfluidic lens

Liquid lenses

21 January 2008

Liquid lenses that can fit in a microchip are now possible, say researchers in the US.


Physics promotion

Soft Matter Physics Promotion - Articles free to download for the month of November!

31 October 2008

A selection of Soft Matter articles on physics topics have been made free for you to download for the whole of November.


Nine images representing the stages in the development of droplet interface bilayers

Latest issue of Molecular BioSystems now published!

14 November 2008

For chemical biology, systems biology, -omics and more see the latest issue of our exciting interdisciplinary journal.


PDMS seal for glass chip

Chips & Tips: A foolproof method for enclosing glass-based LOC devices for electrophoresis

16 January 2008

Colin Mansfield and co-workers describe a simple method to produce a leak free and easily reusible device for electrophoresis.


nerve cell growth in multiple chemical gradients

How do your neurons grow?

08 January 2008

How does a nerve cell find its way to the end of an elephant's trunk? Microfluidic technology could soon provide the answer.


An image showing the patterns of channels

Shrinky Dink® microfluidics

05 December 2007

A children's toy has been turned into a microfluidic research tool in the hands of US engineers.


Analysing genes with a microfluidic processor

Microfluidics prove in-gene-ious

05 December 2007

Analysing genes in individual cells is now simpler, cheaper and more effective thanks to US researchers.


Packaging cells

The viral production line

30 November 2007

Microfactory supplies retrovirus for gene therapy applications.


Miniaturisation prize

Tokeshi wins the Lab on a Chip/Corning Inc Pioneers of Miniaturisation Prize 2007

21 November 2007

Professor Manabu Tokeshi from Nagoya University, Japan won the 'Pioneers of Miniaturisation' Prize.


Close-up of microfluidic cell

Cell culture and lysis on a chip is BASIC

15 November 2007

US researchers have come up with a general strategy to integrate several biological steps in one microchip reactor.


Petra Dittrich

Research Highlights

16 November 2007

Petra Dittrich reviews recent research into animal screening, protein digestion, protein expression profiling and microfluidics for the investigation of tumour induced thrombosis.


Cartoon showing a hand holding a test tube

Computer-aided nanoparticle synthesis

04 October 2007

Fed up with having to optimise your own reactions? Ever wondered why you can't get a computer to do it for you?


Two solutions meeting to form a concentration gradient

Going with the slow flow

04 October 2007

Exploiting osmosis could be the way forward for anticancer drug testing and cell development studies.


The programmable microfluidic device

Digital chips cut down on complexity

02 October 2007

Programmable microfluidic devices could help reduce animal testing, according to scientists in the US.


Call for communications - Image: Cell-Cell communication

Call for communications

27 July 2007

For fast publication of your high impact communications look no further than Lab on a Chip.


Biology in Focus graphic

Biology in Focus

26 June 2007

The latest theme, now available, is microarrays.