Chemical Biology Research Articles

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Chemical biology news and research from across RSC Publishing.

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Advance Articles for Highlights in Chemical Biology: Research Articles

First published on the web: 20�November�2009

Bioconjugated lanthanide luminescent helicates as multilabels for lab-on-a-chip detection of cancer biomarkers
Vanesa Fern�ndez-Moreira, Bo Song, Venkataragavalu Sivagnanam, Anne-Sophie Chauvin, Caroline D. B. Vandevyver, Martin Gijs, Ilkka Hemmil�, Hans-Anton Lehr and Jean-Claude G. B�nzli,� Analyst, 2010
DOI: 10.1039/b922124g

First published on the web: 19�November�2009

Multimodal cell imaging by ruthenium polypyridyl labelled cell penetrating peptides
Lynda Cosgrave, Marc Devocelle, Robert J. Forster and Tia E. Keyes,� Chem. Commun., 2010
DOI: 10.1039/b918611e

Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis
Shu-Ming Li,� Nat. Prod. Rep., 2010
DOI: 10.1039/b909987p

Phosphorane intermediate vs. leaving group stabilization by intramolecular hydrogen bonding in the cleavage of trinucleoside monophosphates: implications for understanding catalysis by the large ribozymes
Tuomas L�nnberg and Maarit Laine,� Org. Biomol. Chem., 2010
DOI: 10.1039/b912042d

Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes
Amy R. Cameron, Siji Anil, Emma Sutherland, Jean Harthill and Graham Rena,� Metallomics, 2010
DOI: 10.1039/b914984h

First published on the web: 18�November�2009

Photonic interaction between quantum dots and gold nanoparticles in discrete nanostructures through DNA directed self-assembly
Qiangbin Wang, Haining Wang, Chenxiang Lin, Jaswinder Sharma, Shengli Zou and Yan Liu,� Chem. Commun., 2010
DOI: 10.1039/b915712c

A synthetic strategy for mimicking the extracellular matrix provides new insight about tumor cell migration
Michael P. Schwartz, Benjamin D. Fairbanks, Robert E. Rogers, Rajagopal Rangarajan, Muhammad H. Zaman and Kristi S. Anseth,� Integr. Biol., 2010
DOI: 10.1039/b912438a

SERS aptasensor from nanorod�nanoparticle junction for protein detection
Yuling Wang, Kyuwan Lee and Joseph Irudayaraj,� Chem. Commun., 2010
DOI: 10.1039/b919607b

First published on the web: 17�November�2009

A click chemistry based coordination polymer inside small heat shock protein
Janice Lucon, Md Joynal Abedin, Masaki Uchida, Lars Liepold, Craig C. Jolley, Mark Young and Trevor Douglas,� Chem. Commun., 2010
DOI: 10.1039/b920868b

Viruses and their potential in bioimaging and biosensing applications
Kai Li, Huong Giang Nguyen, Xiaobing Lu and Qian Wang,� Analyst, 2010
DOI: 10.1039/b911883g

First published on the web: 16�November�2009

FLAG tagging by CuAAC and nanogram-scale purification of the target protein for a bioactive metabolite involved in circadian rhythmic leaf movement in Leguminosae
Yoshiyuki Manabe, Makoto Mukai, Satoko Ito, Nobuki Kato and Minoru Ueda,� Chem. Commun., 2010
DOI: 10.1039/b915843j

Expansion of the mycobacterial PUPylome
Jeramie Watrous, Kristin Burns, Wei-Ting Liu, Anand Patel, Vivian Hook, Vineet Bafna, Clifton E. Barry 3rd, Steve Bark and Pieter C. Dorrestein,� Mol. BioSyst., 2010
DOI: 10.1039/b916104j

Epimeric and amino disaccharide analogs as probes of an -(16)-mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesis
Pui Hang Tam and Todd L. Lowary,� Org. Biomol. Chem., 2010
DOI: 10.1039/b916580k

The detailed balance limit of photochemical energy conversion
Benjamin P. Fingerhut, Wolfgang Zinth and Regina de Vivie-Riedle,� Phys. Chem. Chem. Phys., 2010
DOI: 10.1039/b914552d

Microfabricated arrays for high-throughput screening of cellular response to cyclic substrate deformation
Christopher Moraes, Jan-Hung Chen, Yu Sun and Craig A. Simmons,� Lab Chip, 2010
DOI: 10.1039/b914460a

Synthetic biology in the analysis and engineering of signaling processes
Michael M. K�mpf and Wilfried Weber,� Integr. Biol., 2010
DOI: 10.1039/b913490e

Synthesis and room temperature photo-induced electron transfer in biologically active bis(terpyridine)ruthenium(II)�cytochrome c bioconjugates and the effect of solvents on the bioconjugation of cytochrome c
Joshua R. Peterson, Trevor A. Smith and Pall Thordarson,� Org. Biomol. Chem., 2010
DOI: 10.1039/b919289a

Random network behaviour of protein structures
K. V. Brinda, Saraswathi Vishveshwara and Smitha Vishveshwara,� Mol. BioSyst., 2010
DOI: 10.1039/b903019k

First published on the web: 13�November�2009

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes
Gavin Collie, Anthony P. Reszka, Shozeb M. Haider, Val�rie Gabelica, Gary N. Parkinson and Stephen Neidle,� Chem. Commun., 2009
DOI: 10.1039/b901889a

High flow rate microfluidic device for blood plasma separation using a range of temperatures
Angeles Iv�n Rodr�guez-Villarreal, Martin Arundell, Manuel Carmona and Josep Samitier,� Lab Chip, 2010
DOI: 10.1039/b904531g

The differentiation and engraftment potential of mouse hematopoietic stem cells is maintained after bio-electrospray
Kerol Bartolovic, Napachanok Mongkoldhumrongkul, Simon N. Waddington, Suwan N. Jayasinghe and Steven J. Howe,� Analyst, 2010
DOI: 10.1039/b917813a

An interstrand-wedged duplex composed of alternating DNA base pairs and covalently attached intercalators
Xingguo Liang, Hidenori Nishioka, Toshio Mochizuki and Hiroyuki Asanuma,� J. Mater. Chem., 2010
DOI: 10.1039/b915993b

First published on the web: 12�November�2009

Mechanism of chemical O-glycosylation: from early studies to recent discoveries
Laurel K. Mydock and Alexei V. Demchenko,� Org. Biomol. Chem., 2010
DOI: 10.1039/b916088d

Combining nanotechnology with current biomedical knowledge for the vascular imaging and treatment of atherosclerosis
M. Slevin, L. Badimon, M. Grau-Olivares, M. Ramis, J. Sendra, M. Morrison and J. Krupinski,� Mol. BioSyst., 2010
DOI: 10.1039/b916175a

A palmtop PCR system with a disposable polymer chip operated by the thermosiphon effect
Kwang Hyo Chung, Se Ho Park and Yo Han Choi,� Lab Chip, 2010
DOI: 10.1039/b915022f

Therapeutic applications of hyaluronan
John Gaffney, Sabine Matou-Nasri, Marta Grau-Olivares and Mark Slevin,� Mol. BioSyst., 2010
DOI: 10.1039/b910552m

Application of d⁶ transition metal complexes in fluorescence cell imaging
Vanesa Fern�ndez-Moreira, Flora L. Thorp-Greenwood and Michael P. Coogan,� Chem. Commun., 2010
DOI: 10.1039/b917757d

Human serum albumin coated iron oxide nanoparticles for efficient cell labeling
Jin Xie, Jinhua Wang, Gang Niu, Jing Huang, Kai Chen, Xingguo Li and Xiaoyuan Chen,� Chem. Commun., 2009
DOI: 10.1039/b917195a

Identification and biosynthesis of tropone derivatives and sulfur volatiles produced by bacteria of the marine Roseobacter clade
Verena Thiel, Thorsten Brinkhoff, Jeroen S. Dickschat, Susanne Wickel, J�rg Grunenberg, Irene Wagner-D�bler, Meinhard Simon and Stefan Schulz,� Org. Biomol. Chem., 2010
DOI: 10.1039/b909133e

First published on the web: 11�November�2009

Complete separation of magnetic nanoparticles via chemical cleavage of dextran by ethylenediamine for intracellular uptake
Meng Meng Lin, Shanghua Li, Hyung-Hwan Kim, Hyuck Kim, Hyung Bock Lee, Mamoun Muhammed and Do Kyung Kim,� J. Mater. Chem., 2010
DOI: 10.1039/b918416c

Anticancer platinum complexes as non-innocent compounds for catalysis in aqueous media
Jos� Alem�n, Virginia del Solar and Carmen Navarro-Ranninger,� Chem. Commun., 2009
DOI: 10.1039/b917758b

The influence of proteins on the dispersability and cell-biological activity of silver nanoparticles
S. Kittler, C. Greulich, J. S. Gebauer, J. Diendorf, L. Treuel, L. Ruiz, J. M. Gonzalez-Calbet, M. Vallet-Regi, R. Zellner, M. K�ller and M. Epple,� J. Mater. Chem., 2010
DOI: 10.1039/b914875b

First published on the web: 10�November�2009

Fourier transform infrared (FTIR) spectromicroscopic characterization of stem-like cell populations in human esophageal normal and adenocarcinoma cell lines
R. Zhao, L. Quaroni and A. G. Casson,� Analyst, 2010
DOI: 10.1039/b914311d

An electrochemical molecular switch for one-step, reusable detection of a single-base mutation of DNA
Xiaoyong Jin, Yuehua Fei, Liangliang Zhang, Xueping Liu, Guoli Shen and Ruqin Yu,� Analyst, 2010
DOI: 10.1039/b911672a

Synthetic biology
Ali Tavassoli,� Org. Biomol. Chem., 2010
DOI: 10.1039/b913300n

First published on the web: 09�November�2009

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes
Stuart J. Conway, James Gardiner, Simon J. A. Grove, Melloney K. Johns, Ze-Yi Lim, Gavin F. Painter, Diane E. J. E. Robinson, Christine Schieber, Jan W. Thuring, Leon S.-M. Wong, Meng-Xin Yin, Antony W. Burgess, Bruno Catimel, Phillip T. Hawkins, Nicholas T. Ktistakis, Leonard R. Stephens and Andrew B. Holmes,� Org. Biomol. Chem., 2010
DOI: 10.1039/b913399b

Analytical methodologies for metallomics studies of antitumor Pt-containing drugs
Diego Esteban-Fern�ndez, Estefan�a Moreno-Gordaliza, Benito Ca�as, Mar�a Antonia Palacios and Mar�a Milagros G�mez-G�mez,� Metallomics, 2010
DOI: 10.1039/b911438f
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Complexes of hydroxy(thio)pyrone and hydroxy(thio)pyridinone with Zn(II) and Mo(VI). Thermodynamic stability and insulin-mimetic activity
S�lvia Chaves, Ratomir Jelic, Catarina Mendon�a, Marta Carrasco, Yutaka Yoshikawa, Hiromu Sakurai and M. Am�lia Santos,� Metallomics, 2010
DOI: 10.1039/b914169c

Imaging mass spectrometry of natural products
Eduardo Esquenazi, Yu-Liang Yang, Jeramie Watrous, William H. Gerwick and Pieter C. Dorrestein,� Nat. Prod. Rep., 2009, 26, 1521
DOI: 10.1039/b915674g

Small molecule induced control in duplex and triplex DNA-directed chemical reactions
Mikkel F. Jacobsen, Jens B. Ravnsb�k and Kurt V. Gothelf,� Org. Biomol. Chem., 2010
DOI: 10.1039/b919387a

First published on the web: 07�November�2009

Probing the calcium and sodium local environment in bones and teeth using multinuclear solid state NMR and X-ray absorption spectroscopy
Danielle Laurencin, Alan Wong, Wojciech Chrzanowski, Jonathan C. Knowles, Dong Qiu, David M. Pickup, Robert J. Newport, Zhehong Gan, Melinda J. Duer and Mark E. Smith,� Phys. Chem. Chem. Phys., 2010
DOI: 10.1039/b915708e

First published on the web: 06�November�2009

Host�guest complexations of local anaesthetics by cucurbit[7]uril in aqueous solution
Ian W. Wyman and Donal H. Macartney,� Org. Biomol. Chem., 2010
DOI: 10.1039/b915694a

A direct technique for preparation of magnetically functionalised living yeast cells
Rawil F. Fakhrullin, Javier Garc�a-Alonso and Vesselin N. Paunov,� Soft Matter, 2010
DOI: 10.1039/b914065d

Computational and Systems Biology
Mol. BioSyst., 2009, 5, 1391
DOI: 10.1039/b921381n

Immunosuppressive ultraviolet-A radiation inhibits the development of skin memory CD8 T cells
Sabita Rana, Linda J. Rogers and Gary M. Halliday,� Photochem. Photobiol. Sci., 2010
DOI: 10.1039/b9pp00051h

First published on the web: 05�November�2009

Glycosidase inhibition: assessing mimicry of the transition state
Tracey M. Gloster and Gideon J. Davies,� Org. Biomol. Chem., 2010
DOI: 10.1039/b915870g

A novel bimodal lipidic contrast agent for cellular labelling and tumour MRI
Nazila Kamaly, Tammy Kalber, Gavin Kenny, Jimmy Bell, Michael Jorgensen and Andrew Miller,� Org. Biomol. Chem., 2010
DOI: 10.1039/b910561a

First published on the web: 04�November�2009

Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent
Andrej Maroz, Sujata S. Shinde, Scott G. Franzblau, Zhenkun Ma, William A. Denny, Brian D. Palmer and Robert F. Anderson,� Org. Biomol. Chem., 2010
DOI: 10.1039/b915877d

Radiolabelling of proteins with fluorine-18 via click chemistry
Theres Ramenda, Torsten Kniess, Ralf Bergmann, J�rg Steinbach and Frank Wuest,� Chem. Commun., 2009
DOI: 10.1039/b916075b

Poly(ethylene glycol) cryogels as potential cell scaffolds: effect of polymerization conditions on cryogel microstructure and properties
Yongsung Hwang, Chao Zhang and Shyni Varghese,� J. Mater. Chem., 2010
DOI: 10.1039/b917142h

Sequential CD34 cell fractionation by magnetophoresis in a magnetic dipole flow sorter
Thomas Schneider, Stephan Karl, Lee R. Moore, Jeffrey J. Chalmers, P. Stephen Williams and Maciej Zborowski,� Analyst, 2010
DOI: 10.1039/b908210g

First published on the web: 03�November�2009

Glutathione-bound gold nanoclusters for selective-binding and detection of glutathione S-transferase-fusion proteins from cell lysates
Cheng-Tai Chen, Wei-Jen Chen, Chao-Zong Liu, Ling-Ya Chang and Yu-Chie Chen,� Chem. Commun., 2009
DOI: 10.1039/b916919a

Protein intrinsic disorder and oligomericity in cell signaling
Alexander B. Sigalov,� Mol. BioSyst., 2010
DOI: 10.1039/b916030m

A new method for studying gradient-induced neutrophil desensitization based on an open microfluidic chamber
Thomas M. Keenan, Charles W. Frevert, Aileen Wu, Venus Wong and Albert Folch,� Lab Chip, 2010
DOI: 10.1039/b913494h

First published on the web: 02�November�2009

Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1
Sarah E. Crider, Robert J. Holbrook and Katherine J. Franz,� Metallomics, 2010
DOI: 10.1039/b916899k

An organo-silver compound that shows antimicrobial activity against Pseudomonas aeruginosa as a monomer and plasma deposited film
Neil Poulter, Xavier Munoz-Berbel, Andrew L. Johnson, Andrea J. Dowling, Nicholas Waterfield and A. Tobias A. Jenkins,� Chem. Commun., 2009
DOI: 10.1039/b915467a

Matrix mechanics and receptor�ligand interactions in cell adhesion
Dewi Harjanto and Muhammad H. Zaman,� Org. Biomol. Chem., 2010
DOI: 10.1039/b913064k

Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: applications in ratiometric oxygen sensing in vitro and in regioselective cell killing
Ga-Lai Law, Robert Pal, Lars O. Palsson, David Parker and Ka-Leung Wong,� Chem. Commun., 2009
DOI: 10.1039/b920222f
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First published on the web: 30�October�2009

Mirabilins revisited: polyketide alkaloids from a southern Australian marine sponge, Clathria sp.
Mohamed El-Naggar, Melissa Conte and Robert J. Capon,� Org. Biomol. Chem., 2010
DOI: 10.1039/b915624k

Neutral push-pull chromophores for nonlinear optical imaging of cell membranes
Cyril Barsu, Rouba Cheaib, St�phane Chambert, Yves Queneau, Olivier Maury, Davy Cottet, Hartmut Wege, Julien Douady, Yann Bretonni�re and Chantal Andraud,� Org. Biomol. Chem., 2010
DOI: 10.1039/b915654b