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Interview: An analytical diagnosis
04 December 2008
Maria Montes-Bayón talks about solving medical science problems and how analytical scientists must take the next big step
IUPAC 2009 - Call for Abstracts
21 November 2008
Your chance to take part in 42nd IUPAC Congress (2-7 August 2009, Glasgow, UK). Oral abstract deadline - 16 January 2009
Themed issue on Optical Diagnosis
28 October 2008
Papers are invited on the topic of Optical Diagnosis for publication in a themed issue of the Analyst.
Contents list for The Analyst, issue 12, 2008
Front cover
Analyst, 2008, 133, 1629
DOI: 10.1039/b819574a
Contents and Chemical Technology
Analyst, 2008, 133, 1631
DOI: 10.1039/b819576p
Highlight
New advances in on-line sample preconcentration by capillary electrophoresis using dynamic pH junction
Adam S. Ptolemy and Philip Britz-McKibbin,
Analyst, 2008, 133, 1643
DOI: 10.1039/b808236g
Recent advances in dynamic pH junction are highlighted as a simple strategy to boost concentration sensitivity up to three orders of magnitude for weakly ionic analytes in capillary electrophoresis, while providing improved separation performance that is applicable to complex sample mixtures with minimal off-line sample handling.
Perspective
Univariate calibration by reversed regression of heteroscedastic data: a case study
Qiaoling Charlene Zeng, Elizabeth Zhang and Joel Tellinghuisen,
Analyst, 2008, 133, 1649
DOI: 10.1039/b808667b
In a case study of calibration with heteroscedastic HPLC data, consideration of the 
2 statistic forces the conclusion that the least-squares regression should be reversed.
Papers
Profiling of human urinary phospholipids by nanoflow liquid chromatography/tandem mass spectrometry
Hanna Kim, Eunjeong Ahn and Myeong Hee Moon,
Analyst, 2008, 133, 1656
DOI: 10.1039/b804715d
Shotgun profiling of human urinary phospholipids is introduced by utilizing nanoflow LC-ESI-MS-MS and the efficiency of lipid extraction (ultracentrifugation vs. lyophilization) from 1 mL of urine sample is discussed.
Electrochemical studies on the oxidation of guanine and adenine at cyclodextrin modified electrodes
Abdolkarim Abbaspour and Abolhassan Noori,
Analyst, 2008, 133, 1664
DOI: 10.1039/b806920d
Mechanistic information on the oxidation of guanine and adenine at a cyclodextrin modified carbon paste electrode, and a new method for their determination is illustrated in this study.
Imprinted polymers for chiral resolution of (±)-ephedrine. Part 2: probing pre-polymerisation equilibria in different solvents by NMR
Richard J. Ansell, Dongyao Wang and Janice K. L. Kuah,
Analyst, 2008, 133, 1673
DOI: 10.1039/b806376a
NMR titrations and data fitting have been used to determine multiple association equilibria in the pre-polymerisation stage of molecular imprinting, confirming the strength of the 1 : 1 ephedrine–methacrylic acid interaction in different solvents and the utility of binding sites formed from the 1 : 1 complex.
A new approach prevailing over chloride interference in the photoelectrochemical determination of chemical oxygen demand
Shanqing Zhang and Huijun Zhao,
Analyst, 2008, 133, 1684
DOI: 10.1039/b805095c
A new approach to overcome chloride interferences in the photoelectrochemical determination of chemical oxygen demand (PeCOD
) was proposed and validated. The proposed approach greatly extends the applicability of the PeCOD method, covering a wide range of possible real-world scenarios.
Electrochemical sensor highly selective for estradiol valerate determination based on a modified carbon paste with iron tetrapyridinoporphyrazine
Isabelle V. Batista, Marcos R. V. Lanza, Iara L. T. Dias, Sônia M. C. N. Tanaka, Auro A. Tanaka and Maria D. P. T. Sotomayor,
Analyst, 2008, 133, 1692
DOI: 10.1039/b804462g
This work describes the construction of a highly selective, sensitive and robust sensor for the determination of estradiol valerate hormone as a real alternative to the official method of analysis.
Visualization of local electrochemical activity and local nickel ion release on laser-welded NiTi/steel joints using combined alternating current mode and stripping mode SECM
D. Ruhlig, H. Gugel, A. Schulte, W. Theisen and W. Schuhmann,
Analyst, 2008, 133, 1700
DOI: 10.1039/b804718a
Scanning electrochemical (SECM)
based local conductivity and Ni2+ release measurements on laserwelded NiTi/stainless steel joints identified weld regions as better protected by passivation than the neighboring parental wires.
Spatial metabolic fingerprinting using FT-IR spectroscopy: investigating abiotic stresses on Micrasterias hardyi
Soyab A. Patel, Felicity Currie, Nalin Thakker and Royston Goodacre,
Analyst, 2008, 133, 1707
DOI: 10.1039/b809441a
Spatial metabolic fingerprinting, using infrared microspectroscopy with appropriate chemometrics, was used to investigate abiotic stresses on single algal cells following exposure to active pharmaceutical ingredients.
Analytical and physical optimization of nanohole-array sensors prepared by modified nanosphere lithography
Marie-Pier Murray-Methot, Nicola Menegazzo and Jean-Francois Masson,
Analyst, 2008, 133, 1714
DOI: 10.1039/b808820a
This work describes the analytical and physical properties of nanohole arrays prepared with glancing angle deposition (GLAD) or plasma treatment of a nanosphere lithography (NSL) mask prior to the deposition of a thin Au film.
Novel 
-cyclodextrin modified organic polymeric monolithic substrate for solid phase extraction-room temperature phosphorescence
Zhu Ruohua and Xu Wenting,
Analyst, 2008, 133, 1722
DOI: 10.1039/b804123g
A -CD modified organic polymeric monolithic disk has been synthesized. The material shows the low background, high selectivity and extraction ability as the solid substrate and solid extraction membrane for SPE-RTP.
Rapid and cost-effective detection of sequence-specific DNA by monitoring the electrochemical response of 2
-deoxyguanosine 5-triphosphate in a PCR sample
Xuzhi Zhang, Shufeng Liu, Kui Jiao, Hongwei Gao and Yanjing Shi,
Analyst, 2008, 133, 1729
DOI: 10.1039/b808880b
The electrochemical response of dGTP in the post-PCR sample was employed to estimate whether the sequence-specific DNA was present or not in the DNA template.
Amperometric sensing of ascorbic acid using a disposable screen-printed electrode modified with electrografted o-aminophenol film
Hossam M. Nassef, Laia Civit, Alex Fragoso and Ciara K. O'Sullivan,
Analyst, 2008, 133, 1736
DOI: 10.1039/b808499h
The use of commercial, disposable screen-printed electrodes functionalised via the reduction of an aminophenol diazonium salt, for the selective oxidation of ascorbic acid is reported. The dynamic linear range is 2–20 
M, and a limit of detection of 0.86 M was obtained with an excellent reproducibility (RSD% = 1.98, n = 8).
Highly selective and sensitive assay for paclitaxel accumulation by tumor cells based on selective solid phase extraction and micro-flow liquid chromatography coupled to mass spectrometry
Julio R. Gaspar, Jun Qu, Ninfa L. Straubinger and Robert M. Straubinger,
Analyst, 2008, 133, 1742
DOI: 10.1039/b806856a
High sensitivity and excellent reproducibility has been achieved for quantifying low concentrations of paclitaxel in cell culture medium and cell extracts.
A versatile method for quantification of DNA and PCR products based on time-resolved EuIII luminescence
Bo Song, Caroline D. B. Vandevyver, Emmanuel Deiters, Anne-Sophie Chauvin, Ilkka Hemmilä and Jean-Claude G. Bünzli,
Analyst, 2008, 133, 1749
DOI: 10.1039/b807959e
In the presence of DNA, the luminescence of EuIII complexes quenched by acridine orange is restored, giving rise to a versatile and robust method for the determination of DNA and PCR products.
Detection of triglyceride using an iridium nano-particle catalyst based amperometric biosensor
Wei-Yin Liao, Chung-Chiun Liu and Tse-Chuan Chou,
Analyst, 2008, 133, 1757
DOI: 10.1039/b801703d
An iridium nano-particle modified carbon based biosensor which provides a simple means for triglyceride (TG) measurements in serum by the electrochemical detection/quantification of NADH, produced by the enzymatic degradation of TG, has been fabricated.
Fast capillary electrophoresis coupled with time-of-flight mass spectrometry under separation conditions of high electrical field strengths
Frank-Michael Matysik, Christian Neusüß and Matthias Pelzing,
Analyst, 2008, 133, 1764
DOI: 10.1039/b806349d
Very fast capillary electrophoretic separations in conjunction with time-of-flight mass spectrometry are achieved by using a short separation capillary and field strengths exceeding 1 kV cm-1 which resulted in migration times on the timescale of seconds.
Differences in magnetically induced motion of diamagnetic, paramagnetic, and superparamagnetic microparticles detected by cell tracking velocimetry
Xiaoxia Jin, Yang Zhao, Aaron Richardson, Lee Moore, P. Stephen Williams, Maciej Zborowski and Jeffrey J. Chalmers,
Analyst, 2008, 133, 1767
DOI: 10.1039/b802113a
Motions of diamagnetic, paramagnetic, and superparamagnetic microparticles at varying magnetic fields are measured and discussed. The sensitivity of the cell tracking velocimetry analysis to changes in the particle motion caused by labeling is demonstrated.
Airborne passive Fourier transform infrared remote sensing of methanol vapor from industrial emissions
Boyong Wan and Gary W. Small,
Analyst, 2008, 133, 1776
DOI: 10.1039/b802557f
Airborne passive Fourier transform infrared remote sensing measurements of industrial emissions are used to develop and evaluate automated methods for detecting the signatures of volatile organic compounds.
Determination of the neurotoxin BMAA (-N-methylamino-L-alanine) in cycad seed and cyanobacteria by LC-MS/MS (liquid chromatography tandem mass spectrometry)
Johan Rosén and Karl-Erik Hellenäs,
Analyst, 2008, 133, 1785
DOI: 10.1039/b809231a
Are cyanobacteria linked to neurodegenerative diseases such as Alzheimer's? Previous reports, that cyanobacteria produce large amounts of the neurotoxic amino acid BMAA, are questioned by Swedish researchers.
Immobilization of acetylcholinesterase based on the controllable adsorption of carbon nanotubes onto an alkanethiol monolayer for carbaryl sensing
Dan Du, Minghui Wang, Jie Cai, Yuan Tao, Haiyang Tu and Aidong Zhang,
Analyst, 2008, 133, 1790
DOI: 10.1039/b803851a
The multiwalled carbon nanotube adsorbed onto an alkanethiol self-assembled monolayer surface restores heterogeneous electron transfer between bare electrode and redox system in solution phase.
Back matter
Analyst, 2008, 133, 1796
DOI: 10.1039/b819577n
Back cover
Analyst, 2008, 133, 1799
DOI: 10.1039/b819578c
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