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Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.



Natural products research articles in Organic & Biomolecular Chemistry



Organic & Biomolecular Chemistry publishes many aspects of natural products research - both cutting-edge new work and insightful review articles. Read more about our latest articles below.

Isolation, structure elucidation and total synthesis of a cytotoxic dienone from Echinacea pallida
Stefania Morandi, Federica Pellati, Claudia Ori, Barbara Adinolfi, Paola Nieri, Stefania Benvenuti and Fabio Prati, Org. Biomol. Chem., 2008, 6, 4333
DOI: 10.1039/b812700j
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Controlling the direction of site-selectivity and regioselectivity in RNA ligation by Zn2+-dependent deoxyribozymes that use 2,3-cyclic phosphate RNA substrates
Diana M. Kost, Joseph P. Gerdt, P. I. Pradeepkumar and Scott K. Silverman, Org. Biomol. Chem., 2008, 6, 4391
DOI: 10.1039/b813566e
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Stereoselective synthesis of the hormonally active (25S)-7-dafachronic acid, (25S)-4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid
René Martin, Frank Däbritz, Eugeni V. Entchev, Teymuras V. Kurzchalia and Hans-Joachim Knölker, Org. Biomol. Chem., 2008, 6, 4293
DOI: 10.1039/b815064h
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The first cyclic monomeric 3-alkylpyridinium alkaloid from natural sources: identification, synthesis, and biological activity
Christoph Timm, Christian Volk, Florenz Sasse and Matthias Köck, Org. Biomol. Chem., 2008, 6, 4036
DOI: 10.1039/b808647h
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Total synthesis of siphonazole and its O-methyl derivative, structurally unusual bis-oxazole natural products
Jörg Linder, Alexander J. Blake and Christopher J. Moody, Org. Biomol. Chem., 2008, 6, 3908
DOI: 10.1039/b810855b
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Synthetic studies on the cornexistins: synthesis of (±)-5-epi-hydroxycornexistin
J. Stephen Clark, John M. Northall, Frédéric Marlin, Bastien Nay, Claire Wilson, Alexander J. Blake and Michael J. Waring, Org. Biomol. Chem., 2008, 6, 4012
DOI: 10.1039/b811245b
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Pseudouridines in rRNA helix 69 play a role in loop stacking interactions
Jean-Paul Desaulniers, Yu-Cheng Chang, Raviprasad Aduri, Sanjaya C. Abeysirigunawardena, John SantaLucia, Jr.,Christine S. Chow, Org. Biomol. Chem., 2008, 6, 3892
DOI: 10.1039/b812731j
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Optimisation of chemical protein cleavage for erythropoietin semi-synthesis using native chemical ligation
Jonathan P. Richardson and Derek Macmillan, Org. Biomol. Chem., 2008, 6, 3977
DOI: 10.1039/b811501j
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Palladium-catalyzed total synthesis of euchrestifoline using a one-pot Wacker oxidation and double aromatic C–H bond activation
Konstanze K. Gruner and Hans-Joachim Knölker, Org. Biomol. Chem., 2008, 6, 3902
DOI: 10.1039/b813670j
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Synthesis of (+)-DGDP and (-)-7-epialexine
Timothy J. Donohoe, Matthew D. Cheeseman, Timothy J. C. O'Riordan and Jessica A. Kershaw, Org. Biomol. Chem., 2008, 6, 3896
DOI: 10.1039/b815332a
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First total synthesis of (R,R,R)- and (3R,5S,9R)-bejarol by gold-catalyzed allene cycloisomerization and determination of absolute configuration of the natural product
Yoshinari Sawama, Yuka Sawama and Norbert Krause, Org. Biomol. Chem., 2008, 6, 3573
DOI: 10.1039/b807733a
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Plasticity in gilvocarcin-type C-glycoside pathways: discovery and antitumoral evaluation of polycarcin V from Streptomyces polyformus
Yi-qing Li, Xue-shi Huang, Keishi Ishida, Armin Maier, Gerhard Kelter, Yi Jiang, Gundela Peschel, Klaus-Dieter Menzel, Ming-gang Li, Meng-liang Wen, Li-hua Xu, Susanne Grabley, Heinz-Herbert Fiebig, Cheng-lin Jiang, Christian Hertweck and Isabel Sattler, Org. Biomol. Chem., 2008, 6, 3601
DOI: 10.1039/b808633h
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Catalytic asymmetric synthesis of the alkaloid (+)-myrtine
Maria Gabriella Pizzuti, Adriaan J. Minnaard and Ben L. Feringa, Org. Biomol. Chem., 2008, 6, 3464
DOI: 10.1039/b807575a
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Synthesis of spiroacetal-triazoles as privileged natural product-like scaffolds using click chemistry
Ka Wai Choi and Margaret A. Brimble, Org. Biomol. Chem., 2008, 6, 3518
DOI: 10.1039/b808454h
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Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4
Yanghui Zhang, Jidnyasa Gaekwad, Margreet A. Wolfert and Geert-Jan Boons, Org. Biomol. Chem., 2008, 6, 3371
DOI: 10.1039/b809090d
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The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase
Qingzhi Fan, Fanglu Huang, Peter F. Leadlay and Jonathan B. Spencer, Org. Biomol. Chem., 2008, 6, 3306
DOI: 10.1039/b808734b
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Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties
Ursula Schell, Stephen F. Haydock, Andrew L. Kaja, Isabelle Carletti, Rachel E. Lill, Eliot Read, Lesley S. Sheehan, Lindsey Low, Maria-Jose Fernandez, Friederike Grolle, Hamish A. I. McArthur, Rose M. Sheridan, Peter F. Leadlay, Barrie Wilkinson and Sabine Gaisser, Org. Biomol. Chem., 2008, 6, 3315
DOI: 10.1039/b807914e
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Total synthesis of cucurbitaxanthin A, cycloviolaxanthin and capsanthin 3,6-epoxide by applying a regioselective ring opening of tetrasubstituted epoxides
Yumiko Yamano, Masayoshi Ito and Akimori Wada, Org. Biomol. Chem., 2008, 6, 3421
DOI: 10.1039/b807482h
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A new synthetic approach to (+)-lactacystin based on radical cyclisation of enantiopure -ethynyl substituted serine derivatives to 4-methylenepyrrolidinones
Gerald Pattenden and Gwenaëlla Rescourio, Org. Biomol. Chem., 2008, 6, 3428
DOI: 10.1039/b806681g
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Synthesis and in vitro evaluation of imidazole-based wakayin analogues
Hung Hoang, Xiaofen Huang and Edward B. Skibo, Org. Biomol. Chem., 2008, 6, 3059
DOI: 10.1039/b806883f
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Stereocontrolled synthesis of lepadiformine A
Barry Lygo, Eirene H. M. Kirton and Christopher Lumley, Org. Biomol. Chem., 2008, 6, 3085
DOI: 10.1039/b805951a
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Exploring the substrate specificity of OxyB, a phenol coupling P450 enzyme involved in vancomycin biosynthesis
Katharina Woithe, Nina Geib, Odile Meyer, Tanja Wörtz, Katja Zerbe and John A. Robinson, Org. Biomol. Chem., 2008, 6, 2861
DOI: 10.1039/b805956j
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Reagent switchable stereoselective (1,2) mannoside mannosylation: OH-2 of mannose is a privileged acceptor
Katie J. Doores and Benjamin G. Davis, Org. Biomol. Chem., 2008, 6, 2692
DOI: 10.1039/b803999m
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Antioxidant activity of (+)-bergenin—a phytoconstituent isolated from the bark of Sacoglottis uchi Huber (Humireaceae)
Heitor A. De Abreu, Izandina Aparecida dos S. Lago, Gilmar P. Souza, Dorila Piló-Veloso, Hélio A. Duarte and Antônio Flávio de C. Alcântara, Org. Biomol. Chem., 2008, 6, 2713
DOI: 10.1039/b804385j
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A concise and straightforward total synthesis of (±)-salinosporamide A, based on a biosynthesis model
Nicholas P Mulholland, Gerald Pattenden and Iain A. S. Walters, Org. Biomol. Chem., 2008, 6, 2782
DOI: 10.1039/b803818j
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Trachycladindoles A–G: cytotoxic heterocycles from an Australian marine sponge, Trachycladus laevispirulifer
Robert J. Capon, Chongsheng Peng and Cedric Dooms, Org. Biomol. Chem., 2008, 6, 2765
DOI: 10.1039/b803455a
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