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Investigation of the stereoselectivity of aziridination of cyclic allylic alcohols using chloramine-T
DOI: 10.1039/b811137e
Alanine substitutions (using D-Ala at glycine sites) have raised the melting temperature of the Trp-cage from less than 50 degrees Celsius to 83 degrees Celsius, generating a compact fold with dramatic ring current shifts that do not melt out in NMR experiments.
DOI: 10.1039/b819245f
The antibiotic azithromycin has clinically beneficial effects at sub-inhibitory concentrations against Pseudomonas aeruginosa infections. These effects are, in part, the result of inhibition of bacterial biofilm formation
DOI: 10.1039/b813157k
Live cells illuminated by bimetallic luminescent lanthanide helicates which localize into the endoplasmatic reticulum
DOI: 10.1039/b818229a
The cover depicts a fine blend of different colours that represents the combination of different reagents in a one-pot reaction as reported. The diffusion of colours as shown is reminiscent of sequence of reactions. The transition states responsible for high-level stereoinduction over the above backdrop convey the focus of this manuscript
DOI: 10.1039/b810901j
Novel tetrahydrofuran structures derived from coupling reactions involving sinapyl acetate in Kenaf lignins
DOI: 10.1039/b809464k
Synthesis of spiroacetal-triazoles as privileged natural product-like scaffolds using click chemistry
DOI: 10.1039/b808454h
From a virtual chemical library of quinone-based inhibitors (white) of the dual specificity phosphatase Cdc25B (red, in background), LCAP search algorithms identified the electronically most suitable lead structure (CPK model, front view).
DOI: 10.1039/b806712k
Novel derivatives of UDP-glucose: concise synthesis and fluorescent properties
DOI: 10.1039/b812206g
Synthesis and In Vitro Evaluation of Imidazole-Based Wakayin Analogues
DOI: 10.1039/b806883F
Multi-vicinal fluoroalkanes: a new class of organofluorine compounds
DOI: 10.1039/b809432b
Layer-by-layer deposition of molecular oligoelectrolytes-investigation of assembling and degradation behaviour
DOI: 10.1039/b804290j
Towards sequence selective DNA binding: design, synthesis and DNA binding studies of novel bis-porphyrin peptidic nanostructures
DOI: 10.1039/b803281e
From cartoons to reality: cartoons lead to real-life applications as sensors for blood diagnostics and logic tags for objects.
DOI: 10.1039/b810386k
In vivo enzymatic tagging and in vitro capture of recombinant proteins using an engineered bacterial co-expression system.
DOI: 10.1039/b803258k
The reaction barrier leading to "deactivation" of a chemical warfare simulant is shown to be significantly lower for the hydroperoxide anion than for other nucleophiles thus providing the first example of a gas phase 
-effect and new insights for the decontamination of chemical and biological warfare agents (background).
DOI: 10.1039/b809513m
The picture is taken from the well-known scenic spot - Huangguoshu waterfall in Guizhou Province, China. The inset picture describes chiral secondary amine catalyzed asymmetric cascade Michael-aldol-dehydration reactions, developed by Wang and co-workers. These powerful cascade processes afford efficient approaches to one-pot construction of complex benzo(thio)pyrans and hydroquinolines from simple achiral substances.
DOI: 10.1039/b800245m
Recently, primary amino acids and their derivatives have been demonstrated to be remarkable organocatalysts, which can efficiently convert a wide range of achiral substrates (with Mars as the background) into chiral molecules (Earth in the back) in asymmetric aldol and Mannich reactions.
DOI: 10.1039/b808617f
A photoresponsive chiral molecular plier composed of a ferrocene pivot and zinc porphyrin jaws is able to grab and twist guest molecules.
DOI: 10.1039/B718982F
Epigenetic mechanisms are used to regulate natural product biosynthesis. The application of small-molecule modulators against epigenetic targets uncovers silenced natural product pathways.
DOI: 10.1039/B807360K
The cover shows the 13C NMR traces of enantioenriched propargylic fluorides in the chiral liquid crystalline solvent poly(y-benzylL-glutamate) (PBLG) and chloroform. The data revealed that the electrophilic anti SE2' fluorination of allenylsilanes proceeds with highly efficient transfer of chirality. Cover illustration produced by Dr Karl Harrison (Chemistry Department, University of Oxford).
DOI: 10.1039/B803888K
Metal amidinates can be protonated by the RE-H bonds, leading to catalytic formation of various amidine derivatives from RE-H and carbodiimides.
DOI: 10.1039/b806494f
A number of methodologies allow for the enantioselective functionalisation of [2.2]paracyclophane to give valuable planar chiral molecules.
DOI: 10.1039/b800698a
The N?O-acylshift in threonine-containing phosphopeptides has been investigated and characterised by HPLC-MS and NMR-methods. Phosphopeptides are important for the regulation of protein-protein interactions in signal transduction. The background shows the binding site of the human insulin receptor.
DOI: 10.1039/b718568e
Issue 8, 2008 inside front cover
The natural product oroidin, isolated from marine sponges such as Agelas clathrodes (pictured), provides a unique scaffold for small molecules that inhibit biofilm formation and disperse established Pseudomonas aeruginosa biofilms. Image courtesy of Marc M. Ellis / H2O Pictures.
DOI: 10.1039/b804736g
Ate complex formation between boranes and Si-substituted ylides is reversible, and this affects stereoselectivity.
DOI: 10.1039/B718496D
The image shows the nonribosomal peptide synthetase assembly line which is responsible for the biosynthesis of the lipopeptide antibiotic (CDA) and in the background is a microscope image of an antibiotic producing streptomyces culture.
DOI: 10.1039/B718766C
Issue 6, 2008 inside front cover
In this Perspective, G. Mugesh and B. K. Sarma describe the effect of various thiol cofactors on the biological activity of three major mammalian selenoenzymes, namely glutathione peroxidase, iodothyronine deiodinase and thioredoxin reductase.
DOI: 10.1039/b802984a
Reaction of a free-base porphyrin with iodine acetate gives a radical cation intermediate that can combine with an acetate anion leading to the acetoxylated product or an iodine radical to form the iodo-substituted porphyrin.
DOI: 10.1039/B718542A
Colonies of Pseudomonas aeruginosa grown on Columbia agar containing 50 mg/L 7-N-(?-alanyl)amino-1-pentylphenoxazin-3-one trifluoroacetate after 48 hours incubation at 37 °C (picture courtesy of Larissa Laine, Freeman Hospital, Newcastle upon Tyne, UK)
DOI: 10.1039/B716978G
Both enantiomers of 2-amino-1-phenylethanol (2-APE) were resolved by the use of dehydroabietic acid (DAA), a natural chiral acid, by switching resolving solvents. The crystal structures of both diastereomeric salts, (R)-APE/DAA and (S)-APE/DAA, showed that EtOH molecule was only involved in (R)-APE/DAA to complete the necessary H-bond network.
DOI: 10.1039/b717071h
Issue 3, 2008 Inside front cover
Conformationally rigid oligomers whose facially amphiphilic conformations can be exploited to generate a novel class of compounds that interacts with phospholipid bilayers and shows promise to be potent antimicrobial agents. Dr. Karen Lienkamp and Jeffrey M. Dabkowski are gratefully acknowledged for making the image
DOI: 10.1039/b800425k
The cover picture illustrates recent challenges in aminoglycosides research towards obtaining novel molecular designs as effective antibiotics (selectively targeting bacterial cells) and agents for treatment of human genetic disorders (with increased selectivity to human cells).
DOI: 10.1039/b712690p
High resolution gel-phase proton NMR spectroscopy is a versatile tool for monitoring the thermodynamically controlled self-assembly of polystyrene-bound rotaxanes from their component parts in the surrounding solution phase.
DOI: 10.1039/b719227b
In recent years a remarkable interest in bioorganometallics, such as metallo-nucleosides, has emerged. The cover focuses on the crystal structure of cobalt-modified 5-alkynyl-2'-deoxyuridine, which highlights the antitumor activity of hexacarbonyl dicobalt alkynes against breast cancer cells. Cover Art by Tomasz Sniady.
DOI: 10.1039/b713371e
Not much fits in between sheets of graphite, but there's enough room to accommodate nanometer clusters of nickel. And with reaction partners in the surrounding solution ready to couple as the sheets slide and eventually expose the metal, heterogeneous catalysis can occur to make either C-C or C-H bonds.
DOI: 10.1039/b718411p
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