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2010 NPR Lecture Award nominations open
05 November 2009
Nominations for the 2010 NPR Lecture Award are now open
Directing Biosynthesis 2010: Discovery, Evolution, Function
Further information on this conference to be held from 15 - 17 September 2010 in Durham, UK.
NPR news archive
Contents list for Natural Product Reports, issue 12, 2009
Front cover
Nat. Prod. Rep., 2009, 26, 1509
DOI: 10.1039/b923141m
Contents and Highlights in Chemical Biology
Nat. Prod. Rep., 2009, 26, 1511
DOI: 10.1039/b923142k
Hot off the Press Article
Hot off the press
Robert A. Hill and Andrew Sutherland,
Nat. Prod. Rep., 2009, 26, 1517
DOI: 10.1039/b921623p
A personal selection of 30 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as the tetrameric polysulfur dopamine-derived alkaloid lissoclibadin 8 from the ascidian Lissoclinum cf. badium.
Highlight
Imaging mass spectrometry of natural products
Eduardo Esquenazi, Yu-Liang Yang, Jeramie Watrous, William H. Gerwick and Pieter C. Dorrestein,
Nat. Prod. Rep., 2009, 26, 1521
DOI: 10.1039/b915674g
This Highlight article describes three different imaging mass spectrometry (IMS) approaches, MALDI, DESI and SIMS and their recent applications in the analysis of natural products. IMS has opened up a new avenue for establishing the functional roles of natural products.
Reviews
Bioactive natural products derived from the East African flora
Joseph J. Magadula and Paul Erasto,
Nat. Prod. Rep., 2009, 26, 1535
DOI: 10.1039/b906089h
This review presents the bioactive natural products isolated from medicinal plants growing in East Africa, and aims to coherently document the valuable but scattered reports on their ethnopharmacology.
Chemo-enzymatic synthesis and functional analysis of natural and modified glycostructures
Arne Homann and Jürgen Seibel,
Nat. Prod. Rep., 2009, 26, 1555
DOI: 10.1039/b909990p
In this review we will present strategies for tailoring chemo-emzymatic glycosyltransfer reactions, screening methods such as carbohydrate-based micro-arrays, and metabolic glyco-engineering as a strategy to visualize biological recognition processes for the development of carbohydrate-based vaccines.
The chemistry and biology of LL-37
Matthew F. Burton and Patrick G. Steel,
Nat. Prod. Rep., 2009, 26, 1572
DOI: 10.1039/b912533g
A review summarising the chemistry and biology of the human antimicrobial peptide LL-37, providing analysis of all 117 reported analogues of the natural product in terms of structural features such as hydrophilicity and 
-helicity. Image adapted from the PDB entry (2k6o) derived from Wang, J. Biol. Chem., 2008, 283, 32637, in which hydrophobic residues are shown in green and hydrophilic residues are in blue.
Phylogenetic methods in natural product research
Imke Schmitt and F. Keith Barker,
Nat. Prod. Rep., 2009, 26, 1585
DOI: 10.1039/b910458p
Phylogenetics-based evolutionary analyses are developing rapidly. We summarize recent applications of phylogenetic methods to analyses of natural products and biosynthetic genes, and provide an entrée into the literature and analytical toolkits available.
Back matter
Nat. Prod. Rep., 2009, 26, 1603
DOI: 10.1039/b923144g
Back cover
Nat. Prod. Rep., 2009, 26, 1607
DOI: 10.1039/b923145p
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